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Last Edited: 8/3/2010

Sacramento hepatoblastoma cluster investigation
Written: 1990


In November 1989, the Sacramento press called the California Department of Health Services (DHS) regarding an apparent cluster of hepatoblastoma (a form of liver cancer) cases among Sacramento area children. 

The Cancer Surveillance Section (CSS) obtained abstracts from the Sacramento regional cancer registry for five cases of hepatoblastoma diagnosed from 1987 through 1989.  One of these occurred in a child from outside the Sacramento region, and the remaining four in children residing in Sacramento County at the time of diagnosis. The expected incidence of this cancer would be roughly one case every two years in the region.
 
The Environmental Epidemiology and Toxicology Section reviewed the epidemiologic literature and found that hepatoblastoma had definitely been associated with certain congenital anomalies, and possibly associated with certain parental occupational exposures; viral hepatitis was not associated with hepatoblastoma. A nurse-epidemiologist interviewed the identified case families. The results of the five interviews are summarized.

Executive summary (Size:  42KB)