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Last Edited: 9/28/2005

Correlating agricultural use of organophosphates with outdoor air concentrations: a particular concern for children
Written: 09/01/05


Correlating agricultural use of organophosphates with outdoor air concentrations: a particular concern for children

Martha Harnly,1 Robert McLaughlin,1 Asa Bradman,2 Meredith Anderson,3 Robert Gunier1

Abstract

For the organophosphate pesticide chlorpyrifos, median inhalation non-cancer, acute children’s exposures in agricultural communities, are elevated above reference doses; for diazinon, similar exposures are nearly elevated.  We used multivariate linear regression analysis to examine the temporal and spatial associations between agricultural use and measured air concentrations of chlorpyrifos, chlorpyrifos oxon, diazinon and malathion.  Agricultural use within a three-mile radius on the monitoring day, and use on the two to four prior days, were significantly associated with air concentrations (p < 0.01) for all analytes except malathion; chlorpyrifos oxon showed the strongest association (p < 0.0001).  In the final models, which included weather parameters, the proportion of variance (r2, adjusted for the number of model variables) values for all analytes ranged from 0.28 (p < 0.01) for malathion to 0.65 (p < 0.0001) for diazinon.  Recent cellular, animal and human evidence of toxicity, particularly in newborns, supports the public health concern indicated by initial risk estimates.  Agricultural applications of organophosphates and their oxon products may have substantial volatization and off-field movement and are a probable source of exposures of public health concern.

Full manuscript freely available at http://ehp.niehs.nih.gov/docs/2005/7493/abstract.html

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