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Last Edited: 3/18/2008

Environmental and Genetic Determinants of Puberty
10/2005 - 06/2010

This project is part of the larger Bay Area Breast Cancer & the Environment Research Center (BCERC) at UCSF, which includes animal and epidemiological studies. There are several BCERC sites nationwide, suported by NIEHS and NCI. The epidemiological study focuses on examining determinants of puberty in girls, measured by breast and pubic hair development, as potential contributors to breast cancer risk. The determinants being examined include developmental and lifestyle factors, environmental exposures, and genetic polymorphisms. The project is centered at Kaiser’s Division of Research, with co-investigators from several institutes. The design is a longitudinal cohort, with girls recruited from among Kaiser members at ages 6-7 and followed for 5-6 years with questionnaires, physical examinations and biological samples. As a co-investigator, Dr. Windham of CDPH works on all aspects of the study, focusing on environmental exposures and their measurement by biomarkers, as well as on reproductive factors.